- Further Reading Suggestions
- Welling, P.G. Pharmacokinetics Process and Mathematics. ACS. Washington,
- Notari, R.E., Biopharmaceutics and Clinical Pharmacokinetics. 4th ed.
- Marcel Dekker in, New York (1987)
- D. Wise in Medical Application of Controlled Release Vol II. CRC press
Boca Raton, Florida (1984)
Questions you should be able to answer
- Erythromycin has a pKa of 8.8. Which area of the GI tract will it more
easily pass through the wall, the stomach or the intestine? How about ampicillin
with a pKa of 2.5?
- In cases of drug overdose, the urine of patients who have consumed
basic drugs is made alkaline by administration of sodium bicarbonate, or
made acid by administration of ammonium chloride for acid drugs. Can you
explain the rational behind this treatment?
- Cholestyramine is a nonabsorbable ion exchange resin that can irreversibly
bind digoxin, the heart drug. When Cholestyramine is fed to patients who
are receiving digoxin, the elimination half life of digoxin is markedly
reduced. What is the explanation for this?