4.4.3. Polymers with Pendent Drugs
Another system that is being investigated, especially for cancer drugs, is that of chemically attaching a drug to a polymer backbone, usually a soluble polymer, by means of a bond that is susceptible to enzymatic or hydrolytic breakdown in the body. In many cases this changes the way that the body processes the drug, and it has even been suggested that this is a way of overcoming drug resistance in some cancer cells. In this system very large drug loadings are possible.
Figure 4.4.6. Polymer with pendent drug attached by susceptible linkage.