5.3.2. Sodium alginate/poly-L-lysine microcapsules

Another approach was taken by Leung et al. in which they microencapsulated insulin in an alginate capsule which was then coated with a rate controlling membrane of poly-L-lysine. They observed that with the highest loading of 10 mg of insulin in the capsules, release was 60% in the first day, and essentially complete by day 4. Decreasing the loading did not have a substantial influence on the release pattern. These experiments were performed in vitro, that is in a test tube in the lab as opposed to in vivo, which refers to experimentation in live animals. Figure 5.3.2. shows the results.

Figure 5.3.2. Release of insulin from sodium alginate capsules.