Prerequisites: BMEN E3310 and BMEN E3320 or equivalents. Fundamentals of cardiac mechanics and physiology for the biomedical engineer. Lectures cover cardiac anatomy, passive myocardial constitutive properties, electrical activation, biophysics of calcium cycling and cross-bridge interaction, quantitative models of force generation, ventricular pump function, ventricular-vascular coupling, coronary blood flow, invasive and noninvasive measures of regional and global function, models for predicting ventricular wall stress. Alterations in muscle properties and ventricular function resulting from myocardial infarction, heart failure, and left ventricular assist are discussed. In the laboratory component, students will demonstrate force-length and force-velocity relationships in papillary muscles, conduct simulated ex vivo testing of myocardium, calculate strains from in vivo marker data, examine the impact of geometry and fiber orientation on model stress calculations, and conduct hands-on demonstrations of state-of-the-art ultrasound techniques for noninvasive measurement of cardiac function.
Department: Biomedical Engineering(CBME)
Subject: Biomedical Engineering(BMEN)
School: Fu Foundation School of Engineering and Applied Science
Division: School of Engineering and Applied Science: Graduate
Course ID: 4305