Patent Number: 4,736,866
Date of Patent: April 12, 1988
Inventors: Philip Leder, Chestnut Hill, Mass.; Timothy A.
Stewart, San Francisco, Calif.
Asignee: President and Fellows of Harvard College, Cambridge,
Summary of the Invention:
In general, the invention features a transgenic non-human eukaryotic
animal (preferably a rodent such as a mouse) whose germ cells and
somatic cells contain an activated oncogene sequence introduced
into the animal, or an ancestor of the animal, at an embryonic stage.
The animals of the invention can be used to test a
material suspected of being carcinogen, by exposing the animal to
the material and determining neoplastic growth as an indicator of
The animals of the invention can also be used as tester
animals for materials, e.g. antioxidants such as betacarotine or
vitamin E, thought to confer protection against the development
The aninials of the invention can also be used as
a source of cells for cell culture.
1. A transgenic non-human mammal, all of whose germ cells and somatic
cells contain a recombinant activated oncogene sequence introduced
into said mammal, or an ancestor of said mammal, at an embryonic
11. The mammal of claim 1, said mammal being a rodent.
12. The mammal of claim 11, said rodent being a mouse.